Dynamics of extended-spectrum cephalosporin resistance genes in Escherichia coli from Europe and North America.

ABSTRACT: Extended-spectrum cephalosporins (ESCs) are critically important antimicrobial agents for human and veterinary medicine. ESC resistance (ESC-R) genes have spread worldwide through plasmids and clonal expansion, yet the distribution and dynamics of ESC-R genes in different ecological compartments are poorly understood. Here we use whole genome sequence data of Enterobacterales isolates of human and animal origin from Europe and North America and identify contrasting temporal dynamics. AmpC β-lactamases were initially more dominant in North America in humans and farm animals, only later emerging in Europe. In contrast, specific extended-spectrum β-lactamases (ESBLs) were initially common in animals from Europe and later emerged in North America. This study identifies differences in the relat

SUBMITTER: Zamudio R 

PROVIDER: S-EPMC9744880 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature