Correlations between circulating methylmalonic acid levels and all-cause and cause-specific mortality among patients with diabetes.

ABSTRACT:

Aims

Evidence regarding serum methylmalonic acid (MMA) levels and mortality in individuals with diabetes is limited. This study aimed to evaluate the correlation between MMA and all-cause and cause-specific deaths in patients with diabetes.

Materials and methods

This is a population-based cohort study based on data from both the National Health and Nutrition Examination Survey (NHANES) and National Death Index from 1999 to 2014. We assessed the association of serum MMA concentrations with mortality using Cox proportional hazard models after adjusting for lifestyle, demographic factors, and comorbidities.

Results

Among the 3,097 participants, 843 mortalities occurred during a median follow-up of 4.42 years. There were 242 deaths due to cardiovascular disease (CVD) and

SUBMITTER: Wang J 

PROVIDER: S-EPMC9745031 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature