Dataset Information

Differential influences of serum vitamin C on blood pressure based on age and sex in normotensive individuals.

ABSTRACT:

Aim

Hypertension is among the most prevalent chronic diseases with diverse etiology, affecting over 1 billion people globally. In numerous studies, vitamin C inversely correlated with blood pressure and was suspected to have antihypertensive properties. Currently, there is conflicting evidence regarding the relationship between vitamin C and blood pressure, with most studies being conducted on hypertensive subjects. The principal objective of this project was to investigate the relationship between vitamin C and blood pressure in normotensive adult subjects.

Methods

A total of 2,533 individuals aged 20 years and above were enrolled in the present study from the National Health and Nutrition Examination Survey (NHANES) 2017-2018. Outcome variables were systolic blood pressure (SBP) and diastolic blood pressure (DBP). Serum vitamin C was regarded as an independent variable. EmpowerStats software and R (version 3.4.3) were used to examine the association between vitamin C and SBP or DBP.

Results

Vitamin C was reversely correlated with both SBP (β = -0.02, 95% CI: -0.03 to -0.00, p = 0.0306) and DBP (β = -0.02, 95% CI: -0.04 to -0.01, p = <0.0011) after adjusting all covariates. This reverse relationship may be affected by a number of factors, including a person's gender, age, race, and ethnicity. A U-shaped association between vitamin C and SBP in females and an inverted one between vitamin C and DBP in males were detected, respectively. We further calculated the inflection points at 90.3 μmol/L for females and 40 μmol/L for males. It is somewhat surprising that a reverse U-shaped distribution between vitamin C and SBP and DBP in people over 50 was detected, and the point of inflection of vitamin C were all located at 40 μmol/L.

Conclusion

Vitamin C was negatively correlated with both SBP and DBP in this cross-sectional analysis. However, a U-shaped relationship and an inverted one were also observed in certain people, which implied that, though vitamin C is considered a vital antioxidant, maintaining vitamin C at appropriate levels may be beneficial according to different populations.

SUBMITTER: Huang R

PROVIDER: S-EPMC9745039 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature

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Publications

Differential influences of serum vitamin C on blood pressure based on age and sex in normotensive individuals.

Huang Rui R Song Linhua L Zhao Jingbo J Lei Yuhua Y Li Tian T

Frontiers in nutrition 20221129

<h4>Aim</h4>Hypertension is among the most prevalent chronic diseases with diverse etiology, affecting over 1 billion people globally. In numerous studies, vitamin C inversely correlated with blood pressure and was suspected to have antihypertensive properties. Currently, there is conflicting evidence regarding the relationship between vitamin C and blood pressure, with most studies being conducted on hypertensive subjects. The principal objective of this project was to investigate the relations ...[more]

PMID: 36523333

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Project description:BackgroundStage 1 hypertension influences acute cardiovascular responses to resistance exercises and post-exercise recovery. We examined whether the order of exercises, particularly in agonist-antagonist pairings, can alter these cardiovascular responses. This study compares systolic and diastolic blood pressure responses during agonist and agonist-antagonist paired sets of upper and lower-body resistance exercises with a load of 75% repetition maximum in individuals with normotension and stage 1 hypertension.MethodsA cross-sectional study enrolled 47 participants with sedentary jobs, comprising 30 normotensive individuals (47.8 ± 5.9 years, height 174.8 ± 10.2 cm, weight 77.7 ± 15.4 kg, BMI 25.3 ± 3.6 kg/m2) and 17 hypertensive individuals (54.3 ± 6.0 years, 177.6 ± 11.3 cm, 89.8 ± 16.4 kg, BMI 28.5 ± 4,5 kg/m2). Acute cardiovascular parameters were measured using an arteriograph, a non-invasive device designed to assess vascular stiffness and cardiovascular health, after each set of resistance training.ResultsNo significant differences in systolic blood pressure changes were found between the resistance training methods and aerobic exercise when comparing normotensive and hypertensive individuals. However, significant increases in systolic blood pressure were observed during lower-body exercises (11.3-24.7 mmHg for normotensives and 11.7-24.1 mmHg for hypertensives, p < 0.05). Hypertensive individuals showed slightly higher increases during lower-body supersets (p < 0.05). Regarding diastolic blood pressure, significant decreases were noted during upper-body resistance training for both groups, especially for normotensives (-10.6 to -13.7 mmHg, p < 0.05).ConclusionsAgonist and agonist-antagonist paired set resistance training for both lower and upper-body exercises resulted in similar blood pressure changes in individuals with normotension and stage 1 hypertension. These findings suggest that both methods may have comparable cardiovascular effects across blood pressure.Trial registrationThe study was registered on ClinicalTrials.gov (NCT06047678). Registration date: 31 August 2023.

Project description:Objective: High systolic blood pressure (HSBP) remains the leading risk factor for mortality worldwide; however, limited data have revealed all-cause and cause-specific burdens attributed to HSBP at global and regional levels. This study aimed to estimate the global burden and priority diseases attributable to HSBP by region, sex, and age. Methods: Based on data and evaluation methods from the Global Burden of Diseases, Injuries, and Risk Factors Study 2019, we estimated trends of age-standardized mortality rate (ASMR), the age-standardized rate of disability-adjusted life years (ASDRs), and the age-standardized rate of years lived with disability (ASYRs) attributable to HSBP during 1990-2019. Further, we analyzed cause-specific burdens attributable to HSBP by sex, age, year, and region. Results: Globally, a significant downtrend was found in the ASMR attributed to HSBP while ASYRs did not change substantially during 1990-2019. The majority of HSBP burden has shifted from high-middle sociodemographic index (SDI) regions to lower SDI regions. All-cause and most cause-specific burdens related to HSBP were improved in high SDI regions but the downtrends have stagnated in recent years. Although many cause-specific deaths associated with HSBP declined, chronic kidney disease (CKD) and endocarditis associated deaths were aggravated globally and ischemic heart disease (IHD), atrial fibrillation and flutter, aortic aneurysm (AA), and peripheral artery disease (PAD) associated deaths were on the rise in low/low-middle/middle SDI regions. Additionally, males had higher disease burdens than females. Middle-aged people with CVDs composed the major subgroup affected by HSBP while older people had the highest ASMRs associated with HSBP. Conclusions: This study revealed the global burden and priority diseases attributable to HSBP with wide variation by region, sex, and age, calling for effective and targeted strategies to reduce the prevalence and mortality of HSBP, especially in low/low-middle/middle SDI regions.

Dataset Information

Differential influences of serum vitamin C on blood pressure based on age and sex in normotensive individuals.

Aim

Methods

Results

Conclusion

Publications

Differential influences of serum vitamin C on blood pressure based on age and sex in normotensive individuals.

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