Caspase-1 and the inflammasome promote polycystic kidney disease progression.

ABSTRACT: We and others have previously shown that the presence of renal innate immune cells can promote polycystic kidney disease (PKD) progression. In this study, we examined the influence of the inflammasome, a key part of the innate immune system, on PKD. The inflammasome is a system of molecular sensors, receptors, and scaffolds that responds to stimuli like cellular damage or microbes by activating Caspase-1, and generating critical mediators of the inflammatory milieu, including IL-1β and IL-18. We provide evidence that the inflammasome is primed in PKD, as multiple inflammasome sensors were upregulated in cystic kidneys from human ADPKD patients, as well as in kidneys from both orthologous (PKD1 ^RC/RC or RC/RC) and non-orthologous (jck) mouse models of PKD. Fu

SUBMITTER: Swenson-Fields KI 

PROVIDER: S-EPMC9745047 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature