Heart failure and late-onset Alzheimer's disease: A Mendelian randomization study.

ABSTRACT: Some observational studies suggested that heart failure (HF) is associated with increased risk of late-onset Alzheimer's disease (AD). On the other hand, a recently published Two-Sample Mendelian Randomization (2SMR) study was reported as inconclusive but the estimated odds ratios (ORs) were less than one indicating a potential causal association between genetically predicted HF and lowered risk of AD. Both HF and AD are quite common among elderly persons and frequently occur together resulting in a series of severe medical challenges and increased financial burden on healthcare. It is of great medical and financial interest to further investigate the statistical significance of the potential causal associations between genetically predicted HF and lowered risk of AD using large independen

SUBMITTER: Arega Y 

PROVIDER: S-EPMC9745072 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature