Immune micro-environment and drug analysis of peritoneal endometriosis based on epithelial-mesenchymal transition classification.

ABSTRACT:

Background

Epithelial-mesenchymal transition (EMT) is a complex event that drives polar epithelial cells transform from adherent cells to motile mesenchymal cells, in which are involved immune cells and stroma cells. EMT plays crucial roles in migration and invasion of endometriosis. The interaction of endometrial implants with the surrounding peritoneal micro-environment probably affects the development of peritoneal endometriosis. To date, very few studies have been carried out on peritoneal endometriosis sub-type classification and micro-environment analysis based on EMT. The purpose of this study is to investigate the potential application of EMT-based classification in precise diagnosis and treatment of peritoneal endometriosis.

Method

Based on EMT hallmark genes, 76 pe

SUBMITTER: Quan Q 

PROVIDER: S-EPMC9745086 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature