Exploring the causal relationship between gastroesophageal reflux and oral lesions: A mendelian randomization study.

ABSTRACT: Background: Clinical observations and retrospective studies have observed that patients with gastroesophageal reflux disease (GERD) have an increased probability of dental erosion, periodontitis and oral mucosal lesions and other common oral lesions. However, whether there is a genetic causal relationship between GERD and the occurrence of oral lesions has not been reported. Methods: In this study, we extracted instrumental variables from the largest published summary statistics of the oral lesion phenotype GWAS in UK Biobank (UKBB) and GERD GWAS. Then, we performed a causal inference analysis between GERD and common oral lesions by mendelian randomization (MR) analysis with the R package "TwoSampleMR". Results: We observed a significant causal relationship between GER

SUBMITTER: Shu L 

PROVIDER: S-EPMC9745088 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature