Transcription factors regulating the specification of brainstem respiratory neurons.

ABSTRACT: Breathing (or respiration) is an unconscious and complex motor behavior which neuronal drive emerges from the brainstem. In simplistic terms, respiratory motor activity comprises two phases, inspiration (uptake of oxygen, O₂) and expiration (release of carbon dioxide, CO₂). Breathing is not rigid, but instead highly adaptable to external and internal physiological demands of the organism. The neurons that generate, monitor, and adjust breathing patterns locate to two major brainstem structures, the pons and medulla oblongata. Extensive research over the last three decades has begun to identify the developmental origins of most brainstem neurons that control different aspects of breathing. This research has also elucidated the transcriptional control that secures the s

SUBMITTER: Xia Y 

PROVIDER: S-EPMC9745097 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature