In-depth analysis of the expression and functions of signal transducers and activators of transcription in human ovarian cancer.

ABSTRACT:

Background

Signal transducers and activators of transcription (STAT) transcription factors, a family of genes encoding transcription factors, have been linked to the development of numerous types of tumors. However, there is a relative paucity of a comprehensive investigation of the expression and functional analysis of STATs in ovarian cancer (OV).

Method

Gene expression profile interaction analysis (GEPI2A), Metascape, The Cancer Genome Atlas (TCGA), Kaplan-Meier Plotter, Linkedomics, and CancerSEA databases were used for expression analysis and functional enrichment of STATs in ovarian cancer patients. We screened potential predictive genes and evaluated their prognostic value by constructing the minor absolute shrinkage and selection operator (LASSO) Cox proportional ris

SUBMITTER: Gong X 

PROVIDER: S-EPMC9745122 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature