Mutations matter: An observational study of the prognostic and predictive value of KRAS mutations in metastatic colorectal cancer.

ABSTRACT:

Background

About half of metastatic colorectal cancers (CRCs) harbor Rat Sarcoma (RAS) activating mutations as oncogenic driver, but the prognostic role of RAS mutations is not fully elucidated. Interestingly, specific hotspot mutations have been identified as potential candidates for novel targeted therapies in several malignancies as per G12C. This study aims at evaluating the association between KRAS hotspot mutations and patient characteristics, prognosis and response to antiangiogenic drugs.

Methods

Data from RAS-mutated CRC patients referred to Careggi University Hospital, between January 2017 and April 2022 were retrospectively and prospectively collected. Tumor samples were assessed for RAS mutation status using MALDI-TOF Mass Spectrometry, Myriapod NGS-56G Onco Pane

SUBMITTER: Lavacchi D 

PROVIDER: S-EPMC9745189 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature