The level and integrity of plasma circulating cell-free DNA in patients with primary multiple myeloma.

ABSTRACT:

Background

To evaluate the clinical research related to the level and integrity of circulating free DNA (cfDNA) in the plasma of patients with multiple myeloma (MM).

Methods

The plasma samples of 56 patients with newly diagnosed MM and 60 healthy volunteers were collected. ALU247 fragment and ALU115 fragment were used as target genes, and quantitative polymerase chain reaction (qPCR) was used to assess the plasma of the patient and healthy control groups. The cfDNA level in MM was analyzed, and the ALU247/ALU115 ratio was used to calculate the integrity of cfDNA. The correlation between the cfDNA level and integrity and the clinical characteristics of patients with primary MM was analyzed, and their value in efficacy monitoring and prognostic evaluation was evaluated.

Res

SUBMITTER: Shen Q 

PROVIDER: S-EPMC9745376 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature