Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

The contributions of hypoxia to poor outcomes in pancreatic cancer.

ABSTRACT:

SUBMITTER: Bijlsma MF

PROVIDER: S-EPMC9745382 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature

ACCESS DATA

Json Xml

Publications

The contributions of hypoxia to poor outcomes in pancreatic cancer.

Bijlsma Maarten F MF

Translational cancer research 20221101 11

PMID: 36523300

Similar Datasets

Lorazepam stimulates IL-6 production and is associated with poor survival outcomes in pancreatic cancer

Project description:LOR is associated with worse progression-free survival (PFS) while alprazolam (ALP) is associated with improved PFS, in pancreatic cancer patients receiving chemotherapy. LOR promotes desmoplasia (fibrosis and extracellular matrix protein deposition), inflammatory signaling, and ischemic necrosis. GPR68 is preferentially expressed on human PDAC CAFs, and n-unsubstituted BZDs, such as LOR, significantly increase IL-6 expression and secretion in CAFs in a pH and GPR68-dependent manner. Conversely, ALP, and other GPR68 n-substituted BZDs decrease IL-6 in human CAFs in a pH and GPR68-independent manner. Across many cancer types, LOR is associated with worse survival outcomes relative to ALP and patients not receiving BZDs. We demonstrate that LOR stimulates fibrosis and inflammatory signaling, promotes desmoplasia and ischemic necrosis, and is associated with decreased pancreatic cancer patient survival.

2023-07-19 | GSE237649 | GEO

Lorazepam Stimulates IL6 Production and Is Associated with Poor Survival Outcomes in Pancreatic Cancer.

Project description: Not available

| S-EPMC10502465 | biostudies-literature

Hypoxia-induced metastatic heterogeneity in pancreatic cancer.

Project description: Not available

| S-EPMC12407890 | biostudies-literature

Hypoxia-induced metastatic heterogeneity in pancreatic cancer.

Project description: Not available

| S-EPMC12622147 | biostudies-literature

Circulating stromal cells in resectable pancreatic cancer correlates to pathological stage and predicts for poor clinical outcomes.

Project description: Not available