Sex-specific associations between gut microbiota and skeletal muscle mass in a population-based study.

ABSTRACT:

Background

A gut-muscle axis through which the microbiome influences skeletal muscle has been hypothesized. However, sex-specific association between the characteristics of gut microbiota and skeletal muscle mass has not yet been reported. Herein, we performed sex-specific analyses of faecal microbiota composition for the skeletal muscle mass in a population-based cohort.

Methods

We collected faecal samples of 1052 middle-aged participants (621 men and 431 women) who attended health screenings, and we analysed the intestinal microbiota using 16S rRNA gene sequencing. Relative muscle mass was calculated using a bioelectrical impedance analysis and presented as the skeletal muscle mass index [SMI (%) = total appendicular muscle mass (kg)/weight (kg) × 100]. We categorized the

SUBMITTER: Park CH 

PROVIDER: S-EPMC9745450 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature