The effects of hydrogen treatment in a cigarette smoke solution-induced chronic obstructive pulmonary disease-like changes in an animal model.

ABSTRACT:

Background

Molecular hydrogen, with its antioxidant and anti-inflammatory properties, may be suitable for the prevention and treatment of chronic obstructive pulmonary disease (COPD). This study aims to investigate the therapeutic efficacy of hydrogen-oxygen (H₂/O₂) treatment in cigarette smoke solution (CSS)-induced COPD-like injury in a female BALB/c mouse model.

Methods

Thirty mice were randomly assigned to three groups: Control (n=8), COPD (n=10), and COPD + H₂/O₂ (n=12). CSS was administered by intraperitoneal (IP) injection twice weekly for 6 weeks during the COPD induction phase. Simultaneously, the COPD + H₂/O₂ group started received 75 minutes of inhalation therapy (42% H₂) delivered by the

SUBMITTER: Yang HJ 

PROVIDER: S-EPMC9745525 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature