Changes in fibrinolytic activity and coagulation factors after epicardial left atrial appendage closure in patients with atrial fibrillation.

ABSTRACT:

Background

The left atrial appendage (LAA) is known to be the primary source of thrombus formation in atrial fibrillation (AF). We investigate whether epicardial LAA occlusion (LAAO) from the cardiovascular system has an effect on coagulation and prothrombotic status in AF.

Methods

Twenty-two patients with nonvalvular AF, who were not currently receiving oral anticoagulation (OAC) therapy, participated in a single-center prospective study. We measured fibrinogen and plasminogen levels along with plasma fibrin clot permeability, clot lysis time (CLT) and endogenous thrombin potential (ETP) before the LAAO procedure, at discharge and 1 month afterward.

Results

One month after the LAAO procedure, plasma fibrin clot permeability improved by 39.3% as measured by clots prep

SUBMITTER: Litwinowicz R 

PROVIDER: S-EPMC9745526 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature