Pyruvate dehydrogenase kinase 4 promotes ubiquitin-proteasome system-dependent muscle atrophy.

ABSTRACT:

Background

Muscle atrophy, leading to muscular dysfunction and weakness, is an adverse outcome of sustained period of glucocorticoids usage. However, the molecular mechanism underlying this detrimental condition is currently unclear. Pyruvate dehydrogenase kinase 4 (PDK4), a central regulator of cellular energy metabolism, is highly expressed in skeletal muscle and has been implicated in the pathogenesis of several diseases. The current study was designed to investigated and delineate the role of PDK4 in the context of muscle atrophy, which could be identified as a potential therapeutic avenue to protect against dexamethasone-induced muscle wasting.

Methods

The dexamethasone-induced muscle atrophy in C2C12 myotubes was evaluated at the molecular level by expression of key ge

SUBMITTER: Sinam IS 

PROVIDER: S-EPMC9745560 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature