Gut microbiota analyses of Saudi populations for type 2 diabetes-related phenotypes reveals significant association.

ABSTRACT:

Background

Large-scale gut microbiome sequencing has revealed key links between microbiome dysfunction and metabolic diseases such as type 2 diabetes (T2D). To date, these efforts have largely focused on Western populations, with few studies assessing T2D microbiota associations in Middle Eastern communities where T2D prevalence is now over 20%. We analyzed the composition of stool 16S rRNA from 461 T2D and 119 non-T2D participants from the Eastern Province of Saudi Arabia. We quantified the abundance of microbial communities to examine any significant differences between subpopulations of samples based on diabetes status and glucose level.

Results

In this study we performed the largest microbiome study ever conducted in Saudi Arabia, as well as the first-ever characterizati

SUBMITTER: Al-Muhanna FA 

PROVIDER: S-EPMC9746012 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature