The role of type 2 diabetes in the association between habitual glucosamine use and dementia: a prospective cohort study.

ABSTRACT:

Background

Growing evidence has showed an association between habitual glucosamine use and type 2 diabetes (T2D). However, the effect of habitual glucosamine use on risk of dementia remains poorly understood. Our study aimed to examine the association between glucosamine use and risk of dementia and further to identify the mediating role of T2D in the association.

Methods

A total of 495,942 participants from UK Biobank who completed a questionnaire on habitual glucosamine use were included at baseline (2006-2010) and then followed up for incidence of dementia until 2020. Cox proportional hazard regressions were performed to calculate hazard ratios (HRs) and 95% confidence intervals (CIs) for incident dementia. Markov multi-state models were used to explore the role of incide

SUBMITTER: Xu C 

PROVIDER: S-EPMC9746022 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature