Comprehensive analyses of N⁶ -methyladenosine-related long noncoding RNA profiles with prognosis, chemotherapy response, and immune landscape in small cell lung cancer.

ABSTRACT: Small cell lung cancer (SCLC) is the most devastating subtype of lung cancer with no clinically available prognostic biomarkers. N⁶ -methyladenosine (m⁶ A) and noncoding RNAs play critical roles in cancer development and treatment response. However, little is known about m⁶ A-related long noncoding RNAs (lncRNAs) in SCLC. We used 206 limited-stage SCLC (LS-SCLC) samples from two cohorts to undertake the first and most comprehensive exploration of the m⁶ A-related lncRNA profile in SCLC and constructed a relevant prognostic signature. In total, 289 m⁶ A-related lncRNAs were screened out. We then built a seven-lncRNA-based signature in the training cohort with 48 RNA sequencing data using univariate and multivariate Cox regression models

SUBMITTER: Luo Y 

PROVIDER: S-EPMC9746037 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature