HUCMSCs carrying exenatide prevent T1DM by improving intestinal microflora composition and islet tissue damage repair.

ABSTRACT:

Background

Exenatide is a stable analogue of glucagon-like peptide 1 that can reduce postprandial hyperglycemia and has been utilized as adjunctive therapy for type 1 diabetes mellitus (T1DM). The human umbilical cord is a rich source of MSCs, and human umbilical cord mesenchymal stem cells (hUCMSCs) also show potential to enhance insulin secretion. Here, we aimed to explore the effects of hUCMSCs carrying exenatide in T1DM and further identify the possible mechanisms involved.

Methods

hUCMSCs were isolated from human umbilical cord tissues, identified, and transduced with recombinant lentivirus carrying exenatide to obtain exenatide-carrying hUCMSCs (hUCMSCs@Ex-4).

Results

The results showed that hUCMSCs@Ex-4 restored the blood glucose levels and body weight of NOD m

SUBMITTER: Wang W 

PROVIDER: S-EPMC9746121 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature