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Spatial omics technologies at multimodal and single cell/subcellular level.

ABSTRACT: Spatial omics technologies enable a deeper understanding of cellular organizations and interactions within a tissue of interest. These assays can identify specific compartments or regions in a tissue with differential transcript or protein abundance, delineate their interactions, and complement other methods in defining cellular phenotypes. A variety of spatial methodologies are being developed and commercialized; however, these techniques differ in spatial resolution, multiplexing capability, scale/throughput, and coverage. Here, we review the current and prospective landscape of single cell to subcellular resolution spatial omics technologies and analysis tools to provide a comprehensive picture for both research and clinical applications.

SUBMITTER: Park J

PROVIDER: S-EPMC9746133 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature

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Spatial omics technologies at multimodal and single cell/subcellular level.

Park Jiwoon J Kim Junbum J Lewy Tyler T Rice Charles M CM Elemento Olivier O Rendeiro André F AF Mason Christopher E CE

Genome biology 20221213 1

Spatial omics technologies enable a deeper understanding of cellular organizations and interactions within a tissue of interest. These assays can identify specific compartments or regions in a tissue with differential transcript or protein abundance, delineate their interactions, and complement other methods in defining cellular phenotypes. A variety of spatial methodologies are being developed and commercialized; however, these techniques differ in spatial resolution, multiplexing capability, s ...[more]

PMID: 36514162

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