Rheumatoid arthritis and risk of site-specific cancers: Mendelian randomization study in European and East Asian populations.

ABSTRACT:

Background

The associations of rheumatoid arthritis (RA) with risk of site-specific cancers beyond lymphohematopoietic cancer have been scarcely explored. We conducted a Mendelian randomization investigation of the associations of RA with site-specific cancers in European and East Asian populations.

Methods

Independent genetic variants strongly associated with RA in European and East Asian populations were selected as instrumental variables from genome-wide association studies of 58,284 European individuals (14,361 cases and 43,923 controls) and 22,515 East Asian individuals (4873 cases and 17,642 controls), respectively. The associations of genetic variants with overall and 22 site-specific cancers were extracted from the UK Biobank study (n = 367,561), the FinnGen study (n

SUBMITTER: Yuan S 

PROVIDER: S-EPMC9746148 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature