Sensitivity analysis for live birth bias in the Ulaanbaatar Gestation and Air Pollution Research study.

ABSTRACT: The Ulaanbaatar Gestation and Air Pollution Research (UGAAR) study is a randomized controlled trial of the effects of portable high efficiency particulate air (HEPA) filter air cleaner use during pregnancy on fetal growth and child health outcomes. A challenge with the study is that the outcome variables cannot be measured in the absence of a live birth. Thus pregnancy loss is a competing event for the outcome variables that can obscure the intervention-outcome relationship. This phenomenon is called "live birth bias" in the epidemiological literature, and it is an example of selection bias due to adjustment for variables affected by previous exposure.

Methods

In this investigation, we reanalyzed data from the UGAAR study and examined the impacts of the intervention on three health

SUBMITTER: McCandless LC 

PROVIDER: S-EPMC9746740 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature