Venetoclax Plus Gilteritinib for FLT3-Mutated Relapsed/Refractory Acute Myeloid Leukemia.

ABSTRACT:

Purpose

The FMS-related tyrosine kinase 3 (FLT3) inhibitor gilteritinib is standard therapy for relapsed/refractory FLT3-mutated (FLT3^mut) acute myeloid leukemia (AML) but seldom reduces FLT3^mut burden or induces sustained efficacy. Gilteritinib combines synergistically with the BCL-2 inhibitor venetoclax in preclinical models of FLT3^mut AML.

Methods

This phase Ib open-label, dose-escalation/dose-expansion study (ClinicalTrials.gov identifier: NCT03625505) enrolled patients with FLT3 wild-type and FLT3^mut (escalation) or FLT3^mut (expansion) relapsed/refractory AML. Patients received 400 mg oral venetoclax once daily and 80 mg or 120 mg or

SUBMITTER: Daver N 

PROVIDER: S-EPMC9746764 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature