A brief morning rest period benefits cardiac repair in pressure overload hypertrophy and postmyocardial infarction.

ABSTRACT: Rest has long been considered beneficial to patient healing; however, remarkably, there are no evidence-based experimental models determining how it benefits disease outcomes. Here, we created an experimental rest model in mice that briefly extends the morning rest period. We found in 2 major cardiovascular disease conditions (cardiac hypertrophy, myocardial infarction) that imposing a short, extended period of morning rest each day limited cardiac remodeling compared with controls. Mechanistically, rest mitigates autonomic-mediated hemodynamic stress on the cardiovascular system, relaxes myofilament contractility, and attenuates cardiac remodeling genes, consistent with the benefits on cardiac structure and function. These same rest-responsive gene pathways underlie the pathophysiology of

SUBMITTER: Reitz CJ 

PROVIDER: S-EPMC9746813 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature