A computational modeling approach for predicting multicell spheroid patterns based on signaling-induced differential adhesion.

ABSTRACT: Physiological and pathological processes including embryogenesis and tumorigenesis rely on the ability of individual cells to work collectively to form multicell patterns. In these heterogeneous multicell systems, cell-cell signaling induces differential adhesion between cells that leads to tissue-level patterning. However, the sensitivity of pattern formation to changes in the strengths of signaling or cell adhesion processes is not well understood. Prior work has explored these issues using synthetically engineered heterogeneous multicell spheroid systems, in which cell subpopulations engage in bidirectional intercellular signaling to regulate the expression of different cadherins. While engineered cell systems provide excellent experimental tools to observe pattern formation in cell pop

SUBMITTER: Sivakumar N 

PROVIDER: S-EPMC9747056 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature