Association between age and the host response in critically ill patients with sepsis.

ABSTRACT:

Background

The association of ageing with increased sepsis mortality is well established. Nonetheless, current investigations on the influence of age on host response aberrations are largely limited to plasma cytokine levels while neglecting other pathophysiological sepsis domains like endothelial cell activation and function, and coagulation activation. The primary objective of this study was to gain insight into the association of ageing with aberrations in key host response pathways and blood transcriptomes in sepsis.

Methods

We analysed the clinical outcome (n = 1952), 16 plasma biomarkers providing insight in deregulation of specific pathophysiological domains (n = 899), and blood leukocyte transcriptomes (n = 488) of sepsis patients stratified according to age decades.

SUBMITTER: Michels EHA 

PROVIDER: S-EPMC9747080 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature