Human umbilical cord platelet-rich plasma to treat endometrial pathologies: methodology, composition and pre-clinical models

ABSTRACT: Abstract

STUDY QUESTION

Can human umbilical cord platelet-rich plasma (hUC-PRP) efficiently treat endometrial damage and restore fertility in a preclinical murine model?

SUMMARY ANSWER

Local application of hUC-PRP promotes tissue regeneration and fertility restoration in a murine model of Asherman syndrome and endometrial atrophy (AS/EA).

WHAT IS KNOWN ALREADY

AS/EA are well-described endometrial pathologies that cause infertility; however, there are currently no gold-standard treatments available. Recent reports have described the successful use of human platelet-rich plasma in reproductive medicine, and its regenerative potential is further enhanced using hUC-PRP, due to the ample growth factors and reduced pro-inflammatory cytokines in the latter.

STUDY DE

SUBMITTER:  

PROVIDER: S-EPMC9747096 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature