Defining cellular population dynamics at single-cell resolution during prostate cancer progression.

ABSTRACT: Advanced prostate malignancies are a leading cause of cancer-related deaths in men, in large part due to our incomplete understanding of cellular drivers of disease progression. We investigate prostate cancer cell dynamics at single-cell resolution from disease onset to the development of androgen independence in an in vivo murine model. We observe an expansion of a castration-resistant intermediate luminal cell type that correlates with treatment resistance and poor prognosis in human patients. Moreover, transformed epithelial cells and associated fibroblasts create a microenvironment conducive to pro-tumorigenic immune infiltration, which is partially androgen responsive. Androgen-independent prostate cancer leads to significant diversification of intermediate luminal cell populations ch

SUBMITTER: Germanos AA 

PROVIDER: S-EPMC9747158 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature