Elevated plasma miR-210 expression is associated with atypical genitalia in patients with 46,XY differences in sex development.

ABSTRACT:

Background

Differences of sex development (DSD) is a term used for conditions in which the chromosomal, gonadal or phenotypical sex is atypical. 46,XY DSD patients frequently present undervirilized external genitalia. The expression of different miRNAs in many organs of the male genital system has been reported, and these miRNAs have been associated with testicular function and its disorders, but no description has been related to DSD conditions. This study aimed to evaluate the plasma expression of miR-210 in 46,XY DSD patients who presented atypical genitalia at birth.

Methods

Eighteen 46,XY DSD patients who presented atypical genitalia (undescended testis and/or hypospadias, bifid scrotum or micropenis) at birth and 36 male control individuals were selected. Plasma levels

SUBMITTER: Elias FM 

PROVIDER: S-EPMC9747552 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature