Baicalin improves the energy levels in the prefrontal cortex of mice exposed to chronic unpredictable mild stress.

ABSTRACT: Depression is gradually becoming a primary mental disease threatening human health. Therefore, there is an urgent need to clarify the pathogenesis of depression and identify new effective natural antidepressants. This study aimed to investigate the antidepressant effects of baicalin and explore its potential mechanism in a mouse model of depression induced by chronic unpredictable mild stress (CUMS). Following a 6-week exposure to CUMS, mice were treated with baicalin (10 mg/kg) or fluoxetine (10 mg/kg) for 4 weeks by oral gavage. A sucrose preference test and a forced swimming test were performed to evaluate depression-like behaviors, and the levels of adenosine triphosphate (ATP) in the prefrontal cortex were measured. Moreover, gene expression and enzyme activities related to ATP produc

SUBMITTER: Lu S 

PROVIDER: S-EPMC9747579 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature