Pan-vaccine analysis reveals innate immune endotypes predictive of antibody responses to vaccination.

ABSTRACT: Several studies have shown that the pre-vaccination immune state is associated with the antibody response to vaccination. However, the generalizability and mechanisms that underlie this association remain poorly defined. Here, we sought to identify a common pre-vaccination signature and mechanisms that could predict the immune response across 13 different vaccines. Analysis of blood transcriptional profiles across studies revealed three distinct pre-vaccination endotypes, characterized by the differential expression of genes associated with a pro-inflammatory response, cell proliferation, and metabolism alterations. Importantly, individuals whose pre-vaccination endotype was enriched in pro-inflammatory response genes known to be downstream of nuclear factor-kappa B showed significantly hi

SUBMITTER: Fourati S 

PROVIDER: S-EPMC9747610 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature