Parenteral BCG vaccine induces lung-resident memory macrophages and trained immunity via the gut-lung axis.

ABSTRACT: Aside from centrally induced trained immunity in the bone marrow (BM) and peripheral blood by parenteral vaccination or infection, evidence indicates that mucosal-resident innate immune memory can develop via a local inflammatory pathway following mucosal exposure. However, whether mucosal-resident innate memory results from integrating distally generated immunological signals following parenteral vaccination/infection is unclear. Here we show that subcutaneous Bacillus Calmette-Guérin (BCG) vaccination can induce memory alveolar macrophages (AMs) and trained immunity in the lung. Although parenteral BCG vaccination trains BM progenitors and circulating monocytes, induction of memory AMs is independent of circulating monocytes. Rather, parenteral BCG vaccination, via mycobacterial dissemin

SUBMITTER: Jeyanathan M 

PROVIDER: S-EPMC9747617 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature