Establishment of muscle mass-based indications for the cystatin C test in renal function evaluation.

ABSTRACT:

Background

We aimed to suggest muscle mass-based criteria for using of the cystatin C test for the accurate estimated glomerular filtration rate (eGFR).

Materials and methods

We recruited 138 Korean subjects and evaluated eGFRcr (derived from Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) based on creatinine) was compared to eGFRcys based on cystatin C as the reference value. The skeletal muscle mass index (SMI) by bioelectrical impedance analysis (BIA) was used as representative of muscle mass. Calf circumference (CC) was also evaluated. We defined the patients by eGFRcr as those with values of eGFRcr ≥ 60 mL/min/1.73 m² but eGFRcys < 60 mL/min/1.73 m² as the detection of hidden renal impairment (DHRI). Cut-off values were determined based

SUBMITTER: Yim J 

PROVIDER: S-EPMC9747759 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature