Presence of regulatory T-cells in endometrial cancer predicts poorer overall survival and promotes progression of tumor cells.

ABSTRACT:

Purpose

Endometrial cancer (EC) is one of the most common gynaecologic malignancies. Tumor infiltrating regulatory T-cells (Treg) have been reported to have a prognostic impact in many malignancies. Immunotherapeutic strategies are gaining interest for advanced and recurrent EC cases, where treatment options are rare. Our study was aimed at determining the value of Treg in EC progression.

Methods

EC specimens from 275 patients and 28 controls were screened immunohistochemically for the presence of Treg represented by FoxP3. Correlations with clinicopathological and survival parameters were performed. Functional assays were performed using EC cell lines Ishikawa + and RL95-2 after co-culturing with isolated CD4 + CD25 + CD127dim Treg. To assess the influence of EC on the comp

SUBMITTER: Kolben T 

PROVIDER: S-EPMC9747805 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature