Missing trial results: analysis of the current publication rate of studies in pediatric dialysis from 2003 to 2020.

ABSTRACT:

Background

Decision-making in the field of pediatric dialysis requires evidence from clinical trials, but, similar to other fields of pediatric medicine, might be affected by a low trial publication rate.

Methods

We analyzed the current publication rate, the time to publication, and factors that might be associated with both rate of and time to publication in pediatric dialysis studies registered as completed on ClinicalTrials.gov from 2003 until November 2020.

Results

Fifty-three respective studies were identified. These enrolled 7287 patients in total. 28 of 53 studies (52.8%) had results available. We identified a median time to publication of 20.5 months (range, 3-67). Studies published after the FDA Amendments Act establishment in 2007 were published faster (P = 

SUBMITTER: Patry C 

PROVIDER: S-EPMC9747852 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature