Quantification and dosimetry of small volumes including associated uncertainty estimation.

ABSTRACT:

Background

Accurate quantification of radioactivity in a source of interest relies on accurate registration between SPECT and anatomical images, and appropriate correction of partial volume effects (PVEs). For small volumes, exact registration between the two imaging modalities and recovery factors used to correct for PVE are unreliable. There is currently no guidance relating to quantification or the associated uncertainty estimation for small volumes.

Material and methods

A method for quantification of small sources of interest is proposed, which uses multiple oversized volumes of interest. The method was applied to three Na[¹³¹I]I activity distributions where a Na[¹³¹I]I capsule was situated within a cylindrical phantom containing either zero backgro

SUBMITTER: Carnegie-Peake L 

PROVIDER: S-EPMC9748012 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature