Characterizing spontaneous Ca²⁺ local transients in OPCs using computational modeling.

ABSTRACT: Spontaneous Ca²⁺ local transients (SCaLTs) in isolated oligodendrocyte precursor cells are largely regulated by the following fluxes: store-operated Ca²⁺ entry (SOCE), Na⁺/Ca²⁺ exchange, Ca²⁺ pumping through Ca²⁺-ATPases, and Ca²⁺-induced Ca²⁺-release through ryanodine receptors and inositol-trisphosphate receptors. However, the relative contributions of these fluxes in mediating fast spiking and the slow baseline oscillations seen in SCaLTs remain incompletely understood. Here, we developed a stochastic spatiotemporal computational model to simulate SCaLTs in a homogeneous medium with ionic flow between the extracellular, cytoplasmic, and endoplasmic-reticulum compartments. By simulating the model and

SUBMITTER: Oprea L 

PROVIDER: S-EPMC9748374 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature