PD-L1 is associated with the prognosis of penile cancer: A systematic review and meta-analysis.

ABSTRACT:

Background

Previous studies have explored the role of PD-L1 in the survival outcomes of penile cancer patients with controversies existed. Thus, the meta-analysis was conducted to report and review the association between PD-L1 and survival in penile cancer patients.

Methods

PubMed, Cochrane Library, EMBASE, and Web of Science were all searched, screened, and reviewed by June 1, 2022. Hazard ratio (HR) was used to evaluate the relationship between PD-L1 and survival outcome, and odds ratio (OR) was for tumor features.

Results

Nine retrospective studies (1,003 patients) were incorporated. The prevalence of PD-L1 in patients with penile cancer was 51.4% (95% CI = 42.1%-60.8%, I ² = 88.5%). Higher PD-L1 on tumor cells was related to shorter cancer-speci

SUBMITTER: Lu Y 

PROVIDER: S-EPMC9748474 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature