Endurance exercise under short-duration intermittent hypoxia promotes endurance performance via improving muscle metabolic properties in mice.

ABSTRACT: This study was designed to (1) investigate the effects of acute exercise under intermittent hypoxia on muscle mRNA and protein levels, and (2) clarify the mechanisms by which exercise under intermittent hypoxia improves endurance capacity. Experiment-1: Male mice were subjected to either acute endurance exercise, exercise under hypoxia (14% O₂ ), exercise under intermittent hypoxia (Int, three cycles of room air [10 min] and 14% O₂ [15 min]). At 3 h after exercise under intermittent hypoxia, sirtuin-6 mRNA levels and nuclear prolyl hydroxylases-2 protein levels were significantly upregulated in white gastrocnemius muscle in the Int group. Experiment-2: Mice were assigned to sedentary control (Sed), normoxic exercise-trained (ET), hypoxic exercise-trained (HYP) or exer

SUBMITTER: Suzuki J 

PROVIDER: S-EPMC9748492 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature