Ontology highlight
ABSTRACT:
SUBMITTER: Xu J
PROVIDER: S-EPMC9748621 | biostudies-literature | 2022
REPOSITORIES: biostudies-literature
Xu Jiayun J Sun Shanshan S Zhang Wei W Dong Jianhong J Huang Changgang C Wang Xin X Jia Mengxian M Yang Hao H Wang Yongjie Y Jiang Yuanyuan Y Cao Liying L Huang Zhihui Z
Frontiers in pharmacology 20221130
Glioblastoma (GBM) is the most malignant glioma in brain tumors with low survival and high recurrence rate. Irigenin, as an isoflavone compound extracted from Shegan, has shown many pharmacological functions such as antioxidant, anti-inflammatory and anti-tumor. However, the effects of irigenin on GBM cells and the related molecular mechanisms remain unexplored. In this study, we found that irigenin inhibited the proliferation of GBM cells in a dose-dependent manner by several assays <i>in vitro ...[more]