Unified rhombic lip origins of group 3 and group 4 medulloblastoma.

ABSTRACT: Medulloblastoma, a malignant childhood cerebellar tumour, segregates molecularly into biologically distinct subgroups, suggesting that a personalized approach to therapy would be beneficial¹. Mouse modelling and cross-species genomics have provided increasing evidence of discrete, subgroup-specific developmental origins². However, the anatomical and cellular complexity of developing human tissues³-particularly within the rhombic lip germinal zone, which produces all glutamatergic neuronal lineages before internalization into the cerebellar nodulus-makes it difficult to validate previous inferences that were derived from studies in mice. Here we use multi-omics to resolve the origins of medulloblastoma subgroups in the developing human cerebellum. Molecular

SUBMITTER: Smith KS 

PROVIDER: S-EPMC9748853 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature