Granulovacuolar degeneration bodies are independently induced by tau and α-synuclein pathology.

ABSTRACT:

Background

Granulovacuolar degeneration bodies (GVBs) are intracellular vesicular structures that commonly accompany pathological tau accumulations in neurons of patients with tauopathies. Recently, we developed the first model for GVBs in primary neurons, that requires exogenous tau seeds to elicit tau aggregation. This model allowed the identification of GVBs as proteolytically active lysosomes induced by tau pathology. GVBs selectively accumulate cargo in a dense core, that shows differential and inconsistent immunopositivity for (phosphorylated) tau epitopes. Despite the strong evidence connecting GVBs to tau pathology, these structures have been reported in neurons without apparent pathology in brain tissue of tauopathy patients. Additionally, GVBs and putative GVBs have also

SUBMITTER: Jorge-Oliva M 

PROVIDER: S-EPMC9749177 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature