Stem cell laden nano and micro collagen/PLGA bimodal fibrous patches for myocardial regeneration.

ABSTRACT:

Background

Although the use of cardiac patches is still controversial, cardiac patch has the significance in the field of the tissue engineered cardiac regeneration because it overcomes several shortcomings of intra-myocardial injection by providing a template for cells to form a cohesive sheet. So far, fibrous scaffolds fabricated using electrospinning technique have been increasingly explored for preparation of cardiac patches. One of the problems with the use of electrospinning is that nanofibrous structures hardly allow the infiltration of cells for development of 3D tissue construct. In this respect, we have prepared novel bi-modal electrospun scaffolds as a feasible strategy to address the challenges in cardiac tissue engineering .

Methods

Nano/micro bimodal composite

SUBMITTER: Wee JH 

PROVIDER: S-EPMC9749239 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature