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Association between maternal MTHFR C677T/A1298C combination polymorphisms and IVF/ICSI outcomes: a retrospective cohort study.

ABSTRACT:

SUBMITTER: Lu YJ 

PROVIDER: S-EPMC9749479 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature

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Association between maternal <i>MTHFR</i> C677T/A1298C combination polymorphisms and IVF/ICSI outcomes: a retrospective cohort study.

Lu Yong-Jie YJ   Li Qin Q   Chen Li-Xue LX   Tian Tian T   Kang Jia J   Hao Yong-Xiu YX   Zhou Jian-Suo JS   Wang Yuan-Yuan YY   Yan Li-Ying LY   Li Rong R   Chang Liang L   Qiao Jie J  

Human reproduction open 20221205 1

<h4>Study question</h4>What are the roles of maternal 5,10-methylenetetrahydrofolate reductase (<i>MTHFR</i>) C677T/A1298C combination polymorphisms on the embryological and clinical outcomes of IVF/ICSI?<h4>Summary answer</h4>Our study reveals for the first time that the oocyte maturation potential gradually decreases with a reduction of maternal MTHFR activity determined by combined C677T/A1298C polymorphisms, while embryo quality was worse in women with intermediate MTHFR activity.<h4>What is  ...[more]

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