Genetically predicted sex hormone levels and health outcomes: phenome-wide Mendelian randomization investigation.

ABSTRACT:

Background

Sex hormone-binding globulin (SHBG), testosterone and oestradiol have been associated with many diseases in observational studies; however, the causality of associations remains unestablished.

Methods

A phenome-wide Mendelian randomization (MR) association study was performed to explore disease outcomes associated with genetically proxied circulating SHBG, testosterone and oestradiol levels by using updated genetic instruments in 339 197 unrelated White British individuals (54% female) in the UK Biobank. Two-sample MR analyses with data from large genetic studies were conducted to replicate identified associations in phenome-wide MR analyses. Multivariable MR analyses were performed to investigate mediation effects of hormone-related biomarkers in observed associa

SUBMITTER: Yuan S 

PROVIDER: S-EPMC9749729 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature