GlycoEnzOnto: a GlycoEnzyme pathway and molecular function ontology.

ABSTRACT:

Motivation

The 'glycoEnzymes' include a set of proteins having related enzymatic, metabolic, transport, structural and cofactor functions. Currently, there is no established ontology to describe glycoEnzyme properties and to relate them to glycan biosynthesis pathways.

Results

We present GlycoEnzOnto, an ontology describing 403 human glycoEnzymes curated along 139 glycosylation pathways, 134 molecular functions and 22 cellular compartments. The pathways described regulate nucleotide-sugar metabolism, glycosyl-substrate/donor transport, glycan biosynthesis and degradation. The role of each enzyme in the glycosylation initiation, elongation/branching and capping/termination phases is described. IUPAC linear strings present systematic human/machine-readable descriptions of indi

SUBMITTER: Groth T 

PROVIDER: S-EPMC9750110 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature