In silico evaluation of potential intervention against SARS-CoV-2 RNA-dependent RNA polymerase.

ABSTRACT:

Background

With few available effective interventions, emergence of novel mutants responding poorly to existing vaccines and ever swelling newer waves of infection, SARS-CoV-2 is posing difficult challenges to mankind. This mandates development of newer and effective therapeutics to prevent loss of life and contain the spread of this deadly virus. Nsp12 or RNA-dependent RNA polymerase (RdRp) is a suitable druggable target as it plays a central role in viral replication.

Methodology

Catalytically important conserved amino acid residues of RdRp were delineated through a comprehensive literature search and multiple sequence alignments. PDB ID 7BV2 was used to create binding pockets using SeeSAR and to generate docked poses of the FDA approved drugs on the receptor and estimatin

SUBMITTER: Kapoor S 

PROVIDER: S-EPMC9750507 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature