Using network pharmacology and molecular docking verification to explore the mechanism of ursolic acid in the treatment of osteoporosis.

ABSTRACT: Whether ursolic acid is an effective drug in treatment of osteoporosis (OP) and how it exhibit activity effect on OP is unclear. To investigated the potential molecular mechanism of ursolic acid in the treatment of OP and figured out its possible mechanism is necessary. The target genes of ursolic acid were screened by using the database of traditional chinese medicine systems pharmacology, PubMed database and UniProt database. OP-related target genes were searched by GeneCards database, and utilized online mapping tool to obtain common target genes of component-disease. String database was used to construct a protein-protein interaction (PPI) network of component-disease common target genes and perform topological analysis to screen core target genes. DAVID database was performed gene ont

SUBMITTER: Yang B 

PROVIDER: S-EPMC9750584 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature