Expression and prognosis analyses of the fibronectin type-III domain-containing (FNDC) protein family in human cancers: A Review

ABSTRACT: Despite advancements in early detection and treatment, cancer continues to pose a threat to human health and is the leading cause of death worldwide. According to recent research, the fibronectin type-III domain-containing (FNDC) protein family has been implicated in several different human disorders. However, little is known regarding their expression and prognostic significance in most human malignancies. We carried out a thorough cancer vs. normal expression study using the Oncomine and Tumor Immune Estimation Resource (TIMER) databases, as well as a prognostic evaluation using the Kaplan-Meier (KM) plotter and PrognoScan databases. Oncomine revealed that the mRNA expression levels of FNDC1, FNDC3A, and FNDC3B were higher in most malignancies than in normal tissues, but the mRNA express

SUBMITTER: Jiang H 

PROVIDER: S-EPMC9750624 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature